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Regenerative Medicine · Advanced Biologic

Bone Marrow Aspirate Concentrate (BMAC)

BMAC concentrates cells and growth factors from your own bone marrow. It's a targeted, advanced option — not a first-line treatment — reserved for carefully selected patients.

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Not a cure; usually not covered by insurance. Evidence is still evolving. Not everyone is a candidate.

May be considered for

  • More advanced joint degeneration
  • Bone marrow lesions
  • Patients who haven't responded to PRP

How It Works

A careful, targeted procedure

01

Aspiration

Bone marrow is drawn, typically from the pelvis, using a minimally invasive technique.

02

Concentrate

The sample is processed to concentrate cells and growth factors.

03

Ultrasound-guided injection

The concentrate is delivered precisely to the target under imaging guidance.

Stained bone marrow aspirate cells viewed under a microscope
Bone marrow aspirate contains a mix of cells, seen here under the microscope.
Gloved hand holding a syringe of layered bone marrow concentrate
The processed concentrate, drawn into a syringe.

An honest note: BMAC is a more advanced biologic reserved for select cases. The evidence is still evolving, it is usually not covered by insurance, and it is not a cure or a substitute for surgery when surgery is indicated.

Subchondral BMAC · Joint Preservation

Could subchondral BMAC help you avoid a knee replacement?

Some knee-arthritis pain comes from the bone just beneath the cartilage — the subchondral bone — where painful "bone marrow lesions" can form. Delivering BMAC directly into that bone, rather than only into the joint space, targets the pain at its source and, in the right patient, may relieve symptoms enough to delay or avoid a knee replacement.

For selected patients only. Not a cure, and not a substitute for joint replacement when it is indicated. Individual results vary.

What the research suggests

In a long-term randomized study, patients with arthritis in both knees had one knee treated with subchondral bone-marrow concentrate and the other with a total knee replacement. Over long-term follow-up, many of the concentrate-treated knees avoided replacement altogether.

Reference: Hernigou P, et al. Int Orthop. 2021;45:365–373 & 391–399 — subchondral bone-marrow concentrate vs. contralateral knee arthroplasty at ~15-year follow-up.

Research & Evidence

What the evidence says about BMAC

Marrow-derived

BMAC concentrates cells and growth factors from your own bone marrow; it's studied as an advanced biologic option in select cases.

Reserved for select cases

It's typically considered for more advanced degeneration or when PRP hasn't helped. The evidence is still maturing.

Not a cure

BMAC may relieve symptoms in some patients, but it is not a guaranteed or curative treatment and is usually not insured.

Educational summaries simplified from the orthopedic literature; not a promise of results. We describe BMAC accurately and avoid overstated claims. The evidence for BMAC remains limited and of lower quality; major professional societies urge caution about biologics for arthritis, and BMAC is not FDA-approved as a treatment for arthritis.

BMAC by the Numbers

An honest look at the evidence for bone marrow aspirate concentrate — a promising option where research is still developing.

60-70%
Report Symptom Improvement
Early studies of BMAC for knee arthritis; evidence is still developing and results vary
100%
Your Own Cells
Autologous — drawn from your own bone marrow the same day, nothing synthetic
Same day
Draw, Concentrate & Inject
The entire procedure happens in one visit
6-12
Weeks to Gradual Improvement
Biologic treatments work gradually; response varies by patient and joint

Explore Related Care

Related care

2-Minute Check

Am I a candidate for BMAC treatment?

Answer a few quick questions. This is educational and is not a diagnosis — only an evaluation can tell for sure.

Do you have early arthritis or a tendon injury?

Would you like to explore non-surgical options before considering surgery?

Have you either not yet tried, or not responded to, other conservative care?

Answer all 3 questions to see your result.

Questions, Answered

Frequently asked questions

How is BMAC different from PRP?+

PRP is concentrated from your blood and is often first-line. BMAC is drawn from bone marrow, contains more cell types, and is an advanced option for select cases — such as more advanced degeneration or when PRP hasn't helped.

Is BMAC a stem cell treatment?+

BMAC contains a mix of cells and growth factors from your marrow. We describe it accurately and avoid overstated ‘stem cell’ claims — it is not a cure.

Is BMAC covered by insurance?+

Usually not. We'll explain the cost clearly before any treatment.

Is the procedure painful?+

The aspiration site is numbed. Most patients tolerate it well; we'll walk you through what to expect.

Is BMAC right for your case?

Request a consult and we'll give you an honest, individualized recommendation.

Am I a Candidate? → Call (808) 439-6201
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